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Chelidonic acid

CAS No. 99-32-1

Chelidonic acid( Jerva acid | Jervaic acid | γ-Pyrone-26-dicarboxylic acid )

Catalog No. M20309 CAS No. 99-32-1

Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial?an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Chelidonic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial?an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.
  • Description
    Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial?an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.
  • In Vitro
    Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM.Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation.Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.
  • In Vivo
    Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.
  • Synonyms
    Jerva acid | Jervaic acid | γ-Pyrone-26-dicarboxylic acid
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase-1|NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99-32-1
  • Formula Weight
    184.1
  • Molecular Formula
    C7H4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:4 mg/mL (21.72 mM)
  • SMILES
    OC(=O)c1cc(=O)cc(o1)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Singh D K Gulati K Ray A . Effects of chelidonic acid a secondary plant metabolite on mast cell degranulation and adaptive immunity in rats[J]. International Immunopharmacology 2016 40:229-234.
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